After an entire day of fiddling with MV, PIXI, TexturePacker, Crunch and Powershell, I finally managed to get DXT textures loading in RPG Maker. They work in both .DDS (uncompressed) and .CRN (crunch compression) formats.
Only downside is crunch compression is lossy, so pixel art spritesheets don't look as nice, while .DDS looks perfect but the file size is quite a bit more than optimized PNGs.
Inside you are two wolves. They take in oxygen while getting rid of the Co2 gas in your body...
Ah wait, sorry. Lungs. Not wolves. that'd be silly. Wolves are huge. You probably couldnt even fit one wolf inside you.