Whenever drinking alcohol actually interferes with the well being of either the drinker or the drinker's loved ones. (or strangers, if he/she is stupid enough to get in a car drunk.)
^^ I'd say also when you feel like you can't go without it. I can enjoy a drink, and there are definitely times it sounds nice, but I never feel like I can't function without it.
When you cannot go a single day without drinking at least one beer. At that point, you've got some level of dependence on the substance. My father was an alcoholic... I know practically everything there is to know about the subject because of him.
The second draft of my script is almost done, and I don't think I'm going to write a third draft. I'll make changes to dialogue here and there, but I'm happy with the series of events the way they are.
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