I've seen some games that use both, and with good results. Though that might require tons of balancing... Generally, loot chests can be plentiful, but limited since infinite chests is impossible to my knowledge. But enemy drops can often entail the dreaded item drop grinding. It also depends on...
I may not be an expert or anything, but I find that toying a bit with Physical and Magical Damage rates can help keep a boss tough, but not too tough. Giving a very small percentage of resistance to all forms of damage can help as long as you don't get heavy-handed.
I just had my first real fire. Dad made burgers for lunch and the grill caught fire. He tried to get water but I told him you should never put water on a grease fire. So I got him the fire extinguisher under the sink and we managed to put it out. I can still smell a little of the smoke coming from the patio, but at least it's clearing. It sure was scary though.
Could not for the life of me figure out how to implement the dual/triple techs in Touch the Stars in a player-friendly way. Was describing all the problems to my wife and just rubber-ducked a solution that should work brilliantly.