"You can't think about saving the world.
You have to think about saving one person" - Peter Parker
Focus on one thing at a time, when that's done focus on the next one, and then before you know it, you're done.
3 Extremely Simple solutions:
-Trigger a Switch on before giving the player the item. Turn it off if they lose it.
-Conditional Branch has a tab that says item; anything you put on that branch will only happen if said item is in inventory.
-Same thing for events, they have a "item" condition...
Part of the game experience is, at least for me, discovering things. Experimenting and finding out what works and what doesn't during the game, there's even a sense of mystery as you uncover specific mechanics through the game, and you're like: "What are they going to come up with next?"...
There's a game that's kind of like that, and it's fairly old too. The name's Shadowrun.
It's for SNES/Sega, and while the story has sorta an initial introduction, it's kind of free and you can play around for hours without ever feeling compelled to do anything you don't want to.
The Open Hand scandal got even more spicy. The Completionist streamer Jirard made a video response and tossed a bunch of links and documents, but apparently none of it actually addressed why donations he collected sat for 10 years (way too long to justify). He also seemed to threaten defamation suits vs. people for what amounts to pointing out publicly available records. The IRS should definitely audit.