Yup, like
@Milennin said all you need to do is make a State with the feature "Seal Skill: X" where X is the skill used.
To apply this State to the skill's user, so they can't use that Skill again for the rest of battle, the easiest way to do it is to start your damage formula with
a.addState(n); where n is the State ID.
You could alternatively have the skill execute a Common Event which sets a Variable to the "Last Actor ID to Act" (using Control Variables -> Game Data) and then adds this State to the actor whose ID is that variable (using Change State -> Actor: Variable); this might be useful if for example your skill does not allow a damage formula.
Finally, you could use VS's cooldowns and simply add a cooldown of like 999 turns to the skill, but I don't see why you'd do that when there are better solutions (like the ones described here) that don't require a plugin and don't interact with cooldown modifiers.