I don't exactly undestand what you mean xD. RPG Maker MV is PIXI based basically, at least the renderer. The classes written in RPG Maker MV for graphics are subclasses of PIXI classes, specifically the Sprite class which is written for MV. If you are talking about events its another thing, but since you are on the Learning Javascript board I will talk only about the coding. You can use basically anything for PIXI on RPG Maker MV, if you use the Sprite class you will have no problem with whatever you want to do with PIXI. I wouldn't use PIXI functions directly like,
var picture = PIXI.Sprite.fromImage('
your_picture.png');
That would be using a superclass of a class writter for MV, just use
var picture = new Sprite();
picture.bitmap = ImageManager.load....
It will be basically the same thing, just that one is raw, and the other has been formatted for MV, but all the PIXI Sprite functions are still inside the RPG Maker MV Sprite class, I would use it instead, unless you for some reason want to use PIXI outside RPG Maker, if not, then stick with the Sprite class, it has everything PIXI has and has been written to simplify some things.