Most of the advice for making pixel art for any tile size is going to be the same when working for Gameboy, but the GB has a few extra limitations that make things harder than making most pixel art. Mostly using 4 colors. Working in such a low color environment makes things like contrast, lighting, and positive/negative space much more important, as those things are carrying more weight in defining what your artwork represents to the viewer. You also don't have a whole lot of space to work in, so each pixel conveys way more information and has to be placed more carefully.
As for logistics, I find it easier to size up the graphics to fit MV than I do fixing up MV to use smaller tiles (through plugins and external map editors). Getting the icons working at that size is not easy, when working with 16x16 tiles you only have a 10x10 space to work in because 32 does not divide by 3, but it's doable with some skill.
What exactly is the information you're looking for? The exact limitations of the device? How to make a 4 color tileset look good? Existing resources? How to make a pixel font work without blurring?
