(Time to sound like a snobby art professor) Alright so you notice how in both of those pictures, the main character is the only one with those type of eyes? Example, in the first one, Scooby-Doo has whites in his eyes, but the others don't. And in the second one, Kim has whites in her eyes, but the other girl doesn't. This is not an inconsistency, per-say. This is actually a better and more interesting art style than most cartoons I see now. Like, looking at those pictures, even if by some miracle I didn't know what those shows were, never heard of them before, I would still somewhat be able to pinpoint who the main characters are, just by looking at the eyes. That is for the simple reason that even non-artists have a sense of art. They do, even though they claim to be garbage at it, they still know what works, and what isn't as pleasing to their eyes. And by default, when looking at a piece of art, people's eyes tend to move to the section that most stands out in the piece, and this is again for both artists and regular people. So, when you make a cartoon/anime/game, you obviously want your viewers eyes to move to the main character, unless that character is the type that is supposed to be easily overlooked, and simply average. However, even if that is your case, make them so much so, that they stand out just by being so average. But, back to the eyes, I believe that style to be particularly helpful especially if you don't want your main character to have super flashy clothing or wild hair. Just that subtle hint can draw the player's attention to that character. So, to answer your question, I don't think people would see it as an inconsistency in art style, but as a unique art style. So, if you want that style, I'd say go for it.
