In Borderlands 2, as the playthroughs were ramped up, it was just adding a multiplier to enemy HP. Then when you got to OP levels? Because you were still considered level 72, those higher level enemies got Damage Reduction against your attacks. Oh, and did I forget to mention that enemies got health regen in later playthroughs? And very few characters had damage that scaled up high enough to make it not stupid. The only character that still felt good at the highest levels was a Bloodlust/Mania Krieg build that relied on Release the Beast + Bloodsplosion, because it was such a massively damaging character that the HP multipliers still didn't matter. (Seriously, if you abuse that build properly, you can kill some of the raid bosses, intended to be killed by a full party of 4 at max level, with just one properly timed melee strike bloodsplosion chain). Oh, until you ran into Saturn. Immune to slag, hard to hit crit spots. Hell that thing was a bullet sponge even in the lowest modes. In the final playthrough at the highest levels it was just a giant FU to anyone other than a corrosive pimpernel Sniper Zero build (and the pimpernel alone was just a giant abuse of the mechanics of the game) I love that game, but I seriously wish it didn't become so, so unfun at later levels.